Pharmacological Screening of Gentisic acid for Antidepressant Activity in Unstressed and Stressed Mice

Background: Gentisic acid has been reported to show neuroprotective effect. But its effect on depression is not available in the literature. So we evaluated of this compound depressive behavior unstressed (normal) mice and stressed mice. Materials Methods: Swiss albino male were given unpredictable mild stressors for twenty-one consecutive days produce behavior. (25, 50, 100 mg/kg) fluoxetine (20 administered orally days. Depressive was detected by tail suspension test sucrose preference test. After behavioral testing, biochemical estimations performed plasma brain. Histopathological studies brain also performed. Results: Immobility time remarkably decreased gentisic (50 mg/kg). restored subjected stress paradigm. It lowered concentration nitrite, monoamine oxidase- A, malondialdehyde, TNF-α; increased catalase GSH normal corticosterone indicated protection against hyperchromatic nuclei Conclusion: produced remarkable antidepressant The possible mechanisms observed might be through inhibition MAO-A, amelioration neuroinflammation oxidative stress; Moreover, lowering concentration.